Host colonization with cutaneous commensal induces humoral immunity via formation of dermal tertiary lymphoid organs
نویسندگان
چکیده
Abstract The skin is one of the largest barrier sites which harbors a plethora microorganisms. Whether microbiota promotes humoral responses remains unknown. Here we show that colonization with common commensal Staphylococcus epidermidis profoundly modulates cutaneous immunity results in serum responsiveness antigen-specific IgG antibodies. Such response uncoupled from inflammatory signals and associated induction dermal tertiary lymphoid organs closely resemble classical germinal centers. Of note, such occur tissue autonomous manner as evidenced by preserved antibody repertoire mice deficient professional organs. Our data also uncover non-redundant role for Langerhan’s cells generation specific Further, our work proposes model antigens are collected hair follicle leading to T follicular helper further expand local B cell pool an IL-21-dependent manner. We found induced antibodies can protect host against subsequent infection same microbe demonstrating importance this line defense maintaining protection. Collectively, observations highlight potential organizational flexibility first time demonstrate represent indispensable compartment actively maintains immunity.
منابع مشابه
Editorial: Tertiary Lymphoid Organs (TLOs): Powerhouses of Disease Immunity
1 Institute for Cardiovascular Prevention, Ludwig Maximilians University of Munich, Munich, Germany, 2 German Centre for Cardiovascular Research (DZHK), Munich Heart Alliance, Munich, Germany, 3 Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK, 4 BHF Centre for Excellence in Vascular Science and Medicine, College of Medical, Veterin...
متن کاملArtery Tertiary Lymphoid Organs: Powerhouses of Atherosclerosis Immunity
Artery tertiary lymphoid organs (ATLOs) are atherosclerosis-associated lymphoid aggregates with varying degrees of complexity ranging from small T/B-cell clusters to well-structured lymph node-like though unencapsulated lymphoid tissues. ATLOs arise in the connective tissue that surrounds diseased arteries, i.e., the adventitia. ATLOs have been identified in aged atherosclerosis-prone hyperlipi...
متن کاملLymphoid Neogenesis and Tertiary Lymphoid Organs in Transplanted Organs
The progressive organization of immune effectors into functional ectopic lymphoid structures, named tertiary lymphoid organs (TLO), has been observed in many conditions in which target antigens fail to be eliminated by the immune system. Not surprisingly, TLO have been recurrently identified in chronically rejected allografts. Although significant progress has been made over the last decades in...
متن کاملTertiary Lymphoid Organs in Cancer Tissues
Tertiary lymphoid organs (TLOs) are induced postnatally in non-lymphoid tissues such as those affected by chronic infections, autoimmune diseases, and chronic allograft rejection, and also in cancer tissues. TLOs are thought to provide important lymphocytic functional environments for both cellular and humoral immunity, similar to lymph nodes or Peyer's patches. TLOs have a structure similar to...
متن کاملTertiary Lymphoid Organs in Takayasu Arteritis
OBJECTIVE The role of B cells in the pathogenesis of Takayasu arteritis (TA) is controversial. We aimed to study the presence of tertiary lymphoid organs (TLOs) in the aortic wall of TA patients. METHODS Hematoxylin and eosin-stained sections from aorta specimens from patients with TA were screened for TLOs. The presence of B cell aggregates (CD20), follicular dendritic cells (FDCs, CD21), an...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Immunology
سال: 2023
ISSN: ['1550-6606', '0022-1767']
DOI: https://doi.org/10.4049/jimmunol.210.supp.82.20